ALMA Temporal Phase Stability and the Effectiveness of Water Vapor Radiometer

Atacama Large Millimeter/submillimeter Array (ALMA) will be the world largest mm/submm interferometer, and currently the Early Science is ongoing, together with the commissioning and science verification (CSV). Here we present a study of the temporal phase stability of the entire ALMA system from antennas to the correlator. We verified the temporal phase stability of ALMA using data, taken during the last two years of CSV activities. The data consist of integrations on strong point sources (i.e., bright quasars) at various frequency bands, and at various baseline lengths (up to 600 m). From the observations of strong quasars for a long time (from a few tens of minutes, up to an hour), we derived the 2-point Allan Standard Deviation after the atmospheric phase correction using the 183 GHz Water Vapor Radiometer (WVR) installed in each 12 m antenna, and confirmed that the phase stability of all the baselines reached the ALMA specification. Since we applied the WVR phase correction to all the data mentioned above, we also studied the effectiveness of the WVR phase correction at various frequencies, baseline lengths, and weather conditions. The phase stability often improves a factor of 2 - 3 after the correction, and sometimes a factor of 7 improvement can be obtained. However, the corrected data still displays an increasing phase fluctuation as a function of baseline length, suggesting that the dry component (e.g., N2 and O2) in the atmosphere also contributes the phase fluctuation in the data, although the imperfection of the WVR phase correction cannot be ruled out at this moment.Comment: Proc. SPIE 8444-125, in press (7 pages, 4 figures, 1 table

'Special K' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells: modulation of the adherens junction complex by ketamine

Ketamine, a mild hallucinogenic class C drug, is the fastest growing ‘party drug’ used by 16–24 year olds in the UK. As the recreational use of Ketamine increases we are beginning to see the signs of major renal and bladder complications. To date however, we know nothing of a role for Ketamine in modulating both structure and function of the human renal proximal tubule. In the current study we have used an established model cell line for human epithelial cells of the proximal tubule (HK2) to demonstrate that Ketamine evokes early changes in expression of proteins central to the adherens junction complex. Furthermore we use AFM single-cell force spectroscopy to assess if these changes functionally uncouple cells of the proximal tubule ahead of any overt loss in epithelial cell function. Our data suggests that Ketamine (24–48 hrs) produces gross changes in cell morphology and cytoskeletal architecture towards a fibrotic phenotype. These physical changes matched the concentration-dependent (0.1–1 mg/mL) cytotoxic effect of Ketamine and reflect a loss in expression of the key adherens junction proteins epithelial (E)- and neural (N)-cadherin and β-catenin. Down-regulation of protein expression does not involve the pro-fibrotic cytokine TGFβ, nor is it regulated by the usual increase in expression of Slug or Snail, the transcriptional regulators for E-cadherin. However, the loss in E-cadherin can be partially rescued pharmacologically by blocking p38 MAPK using SB203580. These data provide compelling evidence that Ketamine alters epithelial cell-to-cell adhesion and cell-coupling in the proximal kidney via a non-classical pro-fibrotic mechanism and the data provides the first indication that this illicit substance can have major implications on renal function. Understanding Ketamine-induced renal pathology may identify targets for future therapeutic intervention

High-Frequency Measurements Of The Spectrum Of Sagittarius A*

We report near-simultaneous interferometric measurements of the spectrum of Sagittarius A* over the 5-354 GHz range and single-dish observations that have yielded the first detection of Sgr A* at 850 GHz. We confirm that Sgr A*'s spectrum rises more steeply at short millimeter wavelengths than at centimeter wavelengths, leading to a near-millimeter/submillimeter excess that dominates its luminosity. Below 900 GHz, Sgr A*'s observed luminosity is 70 +/- 30 L.. A new upper limit to Sgr A*'s 24.3 mu m flux, together with a compilation of other extant IR data, imply a far-infrared spectral turnover, which can result from either an intrinsic synchrotron cutoff or excess extinction near Sgr A*. If the former applies, Sgr A*'s total synchrotron luminosity is <10(3) L., while in the latter case it is <3 x 10(4) L. if spherical symmetry also applies.NSF AST96-15025, AST96-13717Astronom

Measurement of Antenna Surfaces from In- and Out-Of-Focus Beam Maps using Astronomical Sources

We present a technique for the accurate estimation of large-scale errors in an antenna surface using astronomical sources and detectors. The technique requires several out-of-focus images of a compact source and the signal-to-noise ratio needs to be good but not unreasonably high. For a given pattern of surface errors, the expected form of such images can be calculated directly. We show that it is possible to solve the inverse problem of finding the surface errors from the images in a stable manner using standard numerical techniques. To do this we describe the surface error as a linear combination of a suitable set of basis functions (we use Zernike polynomials). We present simulations illustrating the technique and in particular we investigate the effects of receiver noise and pointing errors. Measurements of the 15-m James Clerk Maxwell telescope made using this technique are presented as an example. The key result is that good measurements of errors on large spatial scales can be obtained if the input images have a signal-to-noise ratio of order 100 or more. The important advantage of this technique over transmitter-based holography is that it allows measurements at arbitrary elevation angles, so allowing one to characterise the large scale deformations in an antenna as a function of elevation.Comment: 6 pages, 5 figures (accepted by Astronomy & Astrophysics

Out-Of-Focus Holography at the Green Bank Telescope

We describe phase-retrieval holography measurements of the 100-m diameter Green Bank Telescope using astronomical sources and an astronomical receiver operating at a wavelength of 7 mm. We use the technique with parameterization of the aperture in terms of Zernike polynomials and employing a large defocus, as described by Nikolic, Hills & Richer (2006). Individual measurements take around 25 minutes and from the resulting beam maps (which have peak signal to noise ratios of 200:1) we show that it is possible to produce low-resolution maps of the wavefront errors with accuracy around a hundredth of a wavelength. Using such measurements over a wide range of elevations, we have calculated a model for the wavefront-errors due to the uncompensated gravitational deformation of the telescope. This model produces a significant improvement at low elevations, where these errors are expected to be the largest; after applying the model, the aperture efficiency is largely independent of elevation. We have also demonstrated that the technique can be used to measure and largely correct for thermal deformations of the antenna, which often exceed the uncompensated gravitational deformations during daytime observing. We conclude that the aberrations induced by gravity and thermal effects are large-scale and the technique used here is particularly suitable for measuring such deformations in large millimetre wave radio telescopes.Comment: 10 pages, 7 figures (accepted by Astronomy & Astrophysics

Dose-area product measurements during Barium enema radiograph examinations -a Western Cape study

The aim of this study was to obtain a direct measurement of the typical dose delivered to an average adult patient during a barium enema examination. Measurement was done on a sample of 50 patients at three departments, using a dose-area product (DAP) meter. The comparison of the results with UK median levels indicates that the doses measured in South Africa are higher (41 Gy cm2 (dose x area) v. 48 Gy cm2 ). Patient protection can be improved by comparing local practice with national reference levels. The values obtained in this study (first quartile 35 Gy cm2, median 48 Gy cm2, third quartile 84 Gy cm2) are recommended as initial reference dose levels for barium enemas in South Africa

Interferometric Observations of the Nuclear Region of Arp220 at Submillimeter Wavelengths

We report the first submillimeter interferometric observations of an ultraluminous infrared galaxy. We observed Arp220 in the CO J=3-2 line and 342GHz continuum with the single baseline CSO-JCMT interferometer consisting of the Caltech Submillimeter Observatory (CSO) and the James Clerk Maxwell Telescope (JCMT). Models were fit to the measured visibilities to constrain the structure of the source. The morphologies of the CO J=3-2 line and 342GHz continuum emission are similar to those seen in published maps at 230 and 110GHz. We clearly detect a binary source separated by about 1 arcsec in the east-west direction in the 342GHz continuum. The CO J=3-2 visibility amplitudes, however, indicate a more complicated structure, with evidence for a compact binary at some velocities and rather more extended structure at others. Less than 30% of the total CO J=3-2 emission is detected by the interferometer, which implies the presence of significant quantities of extended gas. We also obtained single-dish CO J=2-1, CO J=3-2 and HCN J=4-3 spectra. The HCN J=4-3 spectrum, unlike the CO spectra, is dominated by a single redshifted peak. The HCN J=4-3/CO J=3-2, HCN J=4-3/HCN J=1-0 and CO J=3-2/2-1 line ratios are larger in the redshifted (eastern) source, which suggests that the two sources may have different physical conditions. This result might be explained by the presence of an intense starburst that has begun to deplete or disperse the densest gas in the western source, while the eastern source harbors undispersed high density gas.Comment: 17 pages, 9 figures, 4 Tables. accepted by Ap

Blue Straggler Stars: The Spectacular Population in M80

Using HST-WFPC2 observations in two ultraviolet (UV) filters (F225W and F336W) of the central region of the high density Galactic Globular cluster (GGC) M80 we have identified 305 Blue Straggler Stars (BSS) which represents the largest and most concentrated population of BSS ever observed in a GGC. We also identify the largest, clean sample of evolved BSS yet found. The high stellar density alone cannot explain the BSS, and we suggest that in M80 we are witnessing a transient dynamical state, during which stellar interactions are delaying the core-collapse process leading to an exceptionally large population of collisional-BSS.Comment: 15 pages, 5 figures, Astrophysical Journal Letters, in pres

Characterizing the early vocabulary profiles of preverbal and minimally verbal children with autism spectrum disorder

Abstract Children with autism spectrum disorder (ASD) often have significant language delays. But do they learn language differently than neurotypical toddlers? We compared the lexical skills of 64 preverbal and minimally verbal children with ASD, to 461 vocabulary-size-matched typically developing (TD) toddlers. We also examined social features of verb knowledge using a novel collection of social ratings. Children with ASD produced proportionally more verbs than TD toddlers. Children with ASD produced proportionally more action and food words, while TD toddlers produced proportionally more animal, people words, and animal sounds and sound effects. Children with ASD also produced “mommy” and “daddy” at lower rates. We discuss how these differences may reflect an association between lexical development and weaknesses in social communication. Lay abstract Although preverbal and minimally verbal (PV-MV) children with autism spectrum disorder (ASD) represent a significant portion of the ASD population, we have a limited understanding of and characterization of them. Though it is a given that their lexical profiles contain fewer words, it is important to determine whether: a) the words PV-MV children with ASD produce are similar to the first words typically developing (TD) children produce, or b) there are unique features of the limited words that PV-MV children with ASD produce. The current study compared the early word profiles of PV-MV children with ASD to vocabulary-matched TD toddlers. Children with ASD produced proportionally more verbs than TD toddlers. Also, children with ASD produced proportionally more action and food words, while TD toddlers produced proportionally more animal words, animal sounds and sound effects, and people words. Children with ASD also produced “mommy” and “daddy” at lower rates. Our findings identified several areas of overlap in early word learning; however, our findings also point to differences that may be connected to core weaknesses in social communication (i.e., people words). The findings highlight words and categories that could serve as useful targets for communication intervention with PV-MV children with ASD

Another Non-segregated Blue Straggler Population in a Globular Cluster: the Case of NGC 2419

We have used a combination of ACS-HST high-resolution and wide-field SUBARU data in order to study the Blue Straggler Star (BSS) population over the entire extension of the remote Galactic globular cluster NGC 2419. The BSS population presented here is among the largest ever observed in any stellar system, with more than 230 BSS in the brightest portion of the sequence. The radial distribution of the selected BSS is essentially the same as that of the other cluster stars. In this sense the BSS radial distribution is similar to that of omega Centauri and unlike that of all Galactic globular clusters studied to date, which have highly centrally segregated distributions and, in most cases, a pronounced upturn in the external regions. As in the case of omega Centauri, this evidence indicates that NGC 2419 is not yet relaxed even in the central regions. This observational fact is in agreement with estimated half-mass relaxation time, which is of the order of the cluster age.Comment: in press in the Ap